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Cancer: Squamous Cell Carcinoma
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Reflectance confocal microscopy
(RCM) is a high-resolution, noninvasive tool that is currently approved by the US Food and Drug Administration for obtaining and interpreting images of the skin and cutaneous neoplasms with the goal of decreasing unnecessary biopsy procedures in patients with benign lesions. The second article in this continuing medical education series focuses on identifying key criteria for the diagnosis of common skin cancers —melanoma, basal cell carcinoma, and squamous cell carcinoma.
Source: Journal of the American Academy of Dermatology - June 17, 2020 Category: Dermatology Authors: Neda Shahriari, Jane M. Grant-Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope Tags: Continuing medical education Source Type: research
Racial and ethnic health disparities in dermatology in the United States. Part 2: Disease-specific epidemiology, characteristics, management, and outcomes
Racial and ethnic disparities in dermatology negatively affect outcomes such as mortality and quality of life. Dermatologists and dermatologic surgeons should be familiar with disease-specific inequities that may influence their practice. The second article in this 2-part continuing medical education series highlights gaps in frequency, clinical presentation, management, and outcomes by race and ethnicity. We review cutaneous malignancies including basal cell carcinoma, squamous cell carcinoma, melanoma, Merkel cell carcinoma, dermatofibrosarcoma protuberans, and cutaneous T-cell lymphoma, and inflammatory disorders includ...
Source: Journal of the American Academy of Dermatology - February 6, 2022 Category: Dermatology Authors: Kimberly Shao, Jette Hooper, Hao Feng Tags: Continuing medical education Source Type: research
Cuba Has Made At Least 3 Major Medical Innovations That We Need
By most measures, the United States' business-friendly environment has proven to be fertile for medical innovation. Compared to other countries, America has filed the most patents in the life sciences, is conducting most of the world's clinical trials and has published the most biomedical research. That's what makes the medical prominence of Cuba all the more surprising to those who view a free market as an essential driver of scientific discovery. Cuba is very poor, and yet the country has some of the healthiest, most long-lived residents in the world -- as well as a medical invention or two that could run circl...
Source: Science - The Huffington Post - March 15, 2016 Category: Science Source Type: news
Familial skin cancer syndromes
Nonmelanoma skin cancers (NMSCs) represent the most common malignancies worldwide, with reported incidence rising each year. Both cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), as well as other NMSCs, represent complex diseases with a combination of environmental and genetic risk factors. In general, hereditary cancer syndromes that increase the risk of NMSC fall under several broad categories: those associated with immunodeficiencies, those that affect skin pigmentation, and those that perturb key molecular pathways involved in the pathogenesis of NMSCs.
Source: Journal of the American Academy of Dermatology - February 17, 2016 Category: Dermatology Authors: Prajakta D. Jaju, Katherine J. Ransohoff, Jean Y. Tang, Kavita Y. Sarin Tags: Continuing medical education Source Type: research
Exam 3: Alcohol Consumption and Multiple Dysplastic Lesions Increase Risk of Squamous Cell Carcinoma in the Esophagus, Head, and Neck
Source: Gastroenterology - September 28, 2016 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research
Evidence-Based Medicine: Cutaneous Facial Malignancies: Nonmelanoma Skin Cancer
Learning Objectives: After studying this article, the participant should be able to: 1. Identify clinical features of nonmelanoma skin cancer; 2. Distinguish low-risk versus high-risk basal cell carcinoma and squamous cell carcinoma; 3. Define appropriate management based on current guidelines for various types of basal cell and squamous cell carcinoma.
Summary: Skin malignancies are the most prevalent cancers, and plastic surgeons are often the primary physicians engaged in diagnosis and management of these lesions. Proper management includes distinguishing between high-risk and low-risk lesions and determining treatment...
Source: Plastic and Reconstructive Surgery - December 29, 2016 Category: Cosmetic Surgery Tags: MOC-CME Source Type: research
Exam 3: BRCA1-Associated Protein Increases Invasiveness of Esophageal Squamous Cell Carcinoma
Source: Gastroenterology - October 5, 2017 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research
Reply to: “Cutaneous squamous cell carcinoma progression during imiquimod treatment”
To the Editor: We appreciate the observation made by Dika et al about cutaneous squamous cell carcinoma (cSCC) progression during imiquimod treatment.1 These cases emphasize what we describe in part II of our continuing medical education (CME) article–that topical chemotherapy agents should be limited to the treatment of actinic keratoses and squamous cel l carcinoma in situ and are only Food and Drug Administration–approved for use on actinic keratoses.2 As stated in the CME article, our preferred treatment choice for widespread actinic damage is topical 5-fluorouracil, as imiquimod is not practical for application ...
Source: Journal of the American Academy of Dermatology - March 26, 2018 Category: Dermatology Authors: Syril Keena T. Que, Fiona O. Zwald, Chrysalyne D. Schmults Tags: JAAD online Source Type: research
Reflectance confocal microscopy. Part II. Diagnostic criteria of common benign and malignant neoplasms, dermoscopic and histopathological correlates of key confocal criteria, and diagnostic algorithms
Reflectance confocal microscopy (RCM) is a high-resolution, non-invasive tool currently FDA-approved for obtaining and interpreting images of the skin and cutaneous neoplasms with the goal of decreasing biopsy of benign lesions. Part II of this continuing medical education series focuses on identifying key criteria for the diagnosis of common skin cancers —melanoma, basal cell carcinoma, and squamous cell carcinoma. We contrast these findings with RCM features of common benign lesions—melanocytic nevi, solar lentigo, seborrheic keratosis, lichen planus-like keratosis, and sebaceous hyperplasia.
Source: Journal of the American Academy of Dermatology - June 16, 2020 Category: Dermatology Authors: Neda Shahriari, Jane M. Grant-Kels, Harold Rabinovitz, Margaret Oliviero, Alon Scope Source Type: research
New Developments in the Management of Cutaneous Squamous Cell Carcinoma
Learning Objectives:
After studying this article, the participant should be able to: 1. List important prognostic features that affect cutaneous squamous cell carcinoma risk. 2. Summarize the changes to the AJCC Cancer Staging Manual, Eighth Edition, staging system for cutaneous squamous cell carcinoma. 3. Evaluate the draining nodal basin with appropriate imaging modalities. 4. Recommend adjuvant radiation therapy in the correct clinical setting for high-risk tumors. 5. Recognize the currently available treatments for advanced cutaneous squamous cell carcinoma.
Summary:
This continuing medical education article...
Source: Plastic and Reconstructive Surgery - March 1, 2021 Category: Cosmetic Surgery Tags: CME Source Type: research
The role of radiation therapy in the management of cutaneous malignancies. Part II: When is radiation therapy indicated?
Radiation therapy may be performed for a variety of cutaneous malignancies depending on patient health status, tumor clinical and histologic features, patient preference, and resource availability. Dermatologists should be able to recognize the clinical scenarios in which radiation therapy is appropriate as this may reduce morbidity, decrease risk of disease recurrence, and improve quality of life. The second article in this 2-part continuing medical education series focuses on the most common indications for radiation therapy in the treatment of basal cell carcinoma, cutaneous squamous cell carcinoma, dermatofibrosarcoma ...
Source: Journal of the American Academy of Dermatology - June 8, 2021 Category: Dermatology Authors: Kelly M. Wilmas, Wesley B. Garner, Matthew T. Ballo, Susan L. McGovern, Deborah F. MacFarlane Source Type: research
Racial/Ethnic Health Disparities in Dermatology in the United States Part 2: Disease-specific Epidemiology, Characteristics, Management, and Outcomes
Racial and ethnic disparities in dermatology negatively affect outcomes such as mortality and quality of life. Dermatologists and dermatologic surgeons should be familiar with disease-specific inequities that may influence their practice. The second article in this two-part continuing medical education series highlights gaps in frequency, clinical presentation, management, and outcomes by race and ethnicity. We review cutaneous malignancies including basal cell carcinoma, squamous cell carcinoma, melanoma, Merkel cell carcinoma, dermatofibrosarcoma protuberans, and cutaneous T cell lymphoma, and inflammatory disorders incl...
Source: Journal of the American Academy of Dermatology - February 6, 2022 Category: Dermatology Authors: Kimberly Shao, Jette Hooper, Hao Feng Source Type: research
Risk of melanoma and nonmelanoma skin cancer with immunosuppressants, part I: Calcineurin inhibitors, thiopurines, IMDH inhibitors, mTOR inhibitors, and corticosteroids
Immunosuppression is a well-documented risk factor for skin cancer, as exemplified by the 65- to 250-fold higher squamous cell carcinoma risk, 10-fold higher basal cell carcinoma risk, and 0 to 8-fold higher melanoma risk in solid organ transplant recipients (SOTRs) receiving potent, prolonged courses of immunosuppressive therapies. Numerous immune system components have been shown to either suppress or promote tumor growth, and immunosuppressive drugs may have additional effects on proliferative pathways independent of the immune system.
Source: Journal of the American Academy of Dermatology - November 29, 2022 Category: Dermatology Authors: Margaret Ann Kreher, Mary Margaret B. Noland, Sailesh Konda, Maria I. Longo, Rodrigo Valdes-Rodriguez Tags: Continuing medical education Source Type: research
Immunotherapy for keratinocyte cancers. Part II: Identification and management of cutaneous side effects of immunotherapy treatments
Keratinocytic cancers (KCs), specifically cutaneous squamous cell and basal cell carcinomas, can respond to topical, intralesional, or systemic immunotherapies, but cutaneous adverse events (CAEs) may occur. Understanding these risks, early recognition of these CAEs, and effective treatment may enable patients to continue their anticancer immunotherapies without dose impact. Immune checkpoint inhibitor-related CAEs after KCs can have multiple clinical presentations, with specific observed types including psoriasis and bullous pemphigoid.
Source: Journal of the American Academy of Dermatology - June 1, 2023 Category: Dermatology Authors: Anne Lynn S. Chang, Lisa Zaba, Bernice Y. Kwong Tags: Continuing medical education Source Type: research
Building a gold standard to construct search filters: a case study with biomarkers for oral cancer.
CONCLUSIONS: The gold standard dataset is likely to be high quality and useful for future development and evaluation of filters for OSCC studies of potential prognostic biomarkers.
IMPLICATIONS: The methodology we used is generalizable to other domains requiring a reference standard to evaluate the performance of search filters. A gold standard is essential because the labels regarding relevance enable computation of diagnostic metrics, such as sensitivity and specificity. Librarians and informationists with data analysis skills could contribute to developing gold standard datasets and subsequent filters tuned for thei...
Source: Journal of the Medical Library Association : JMLA - January 4, 2015 Category: Databases & Libraries Tags: J Med Libr Assoc Source Type: research
